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KMID : 0613820120220060844
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Journal of Life Science
2012 Volume.22 No. 6 p.844 ~ p.851
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Antioxidant and Cancer Cell Growth Inhibition Activity of Five Different Varieties of Artemisia Cultivars in Korea
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Kim Ra-Jeong
Kang Min-Jung
Hwang Cho-Rong
Jung Woo-Jae
Shin Jung-Hye
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Abstract
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Antioxidant and cancer cell growth inhibition activity of hot water extract from five different varieties of Artemisia (A. Argyi H., A. iwayomogi Kitamura, A. Princeps Var Orien talis HARA, A. princeps Pampanini and A. annua L.) in Korea was studied. We determined the phenol and flavonoid contents and examined antioxidant assay, such as DPPH, NO radical scavenging, activity ferric-reducing antioxidant power (FRAP), and bleaching inhibition activity in the β-carotene linolic acid system. Also, we performed HeLa and MCF-7 cancer cell growth inhibition assay of Artemisia extracts. Total phenol and flavonoid contents were the highest in A. iwayomogi Kitamura followed by A. Argyi H. DPPH radical scavenging activity was the highest in A. Argyi H. at 50 μg/ml concentration, NO radical scavenging activity was more than 50% in A. Princeps Var Orien talis HARA, A. princeps Pampanini, and A. annua L. at 200 μg/ml concentration. FRAP was higher in A. Argyi H. and A. iwayomogi Kitamura. Antioxidant activity in the β-carotene linolinolic system was also higher in A. Argyi H. and A. iwayomogi Kitamura by 60.50% and 56.90% at 100 μg/ml concentration, respectively. In cancer cell growth inhibition activities at 400 μg/ml concentration, A. iwayomogi Kitamura showed greater than 80% on HeLa cell. A. princeps Pampanini and A. Argyi H. extract had growth inhibition activities greater than 80% on MCF cell. The results of this study suggest that the antioxidant and anticancer activities in various Artemisia are a promising source of functional food ingredients.
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KEYWORD
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Artemisia, antioxidant activity, cancer cell growth inhibition activity
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